edition of the Federal Register. We included an untreated check and ALL plots, including the check, received 10.5 oz/ac of Quilt Xcel at Feekes GS 10.5 (heading). documents in the last year, 36 In the event of a Toxic or Transport Emergency in the UK please telephone 01484538444 at any time. The OFR/GPO partnership is committed to presenting accurate and reliable In the rat reproduction study, reproductive toxicity was not observed, but decreased pup survival Start Printed Page 12742and decreased pup body weight/body-weight gain during lactation were observed above the limit dose with only reduced body weight and food consumption observed in the parental animals (>1,200 mg/kg/day). It inhibits vertical shoot growth, while producing healthy, durable blades in turfgrass. Therefore, acute aggregate risk is equivalent to the acute dietary risk as discussed in Unit III.C.1.i. An anonymous citizen objected to the presence of any pesticide residues on food. Acute aggregate risk takes into account exposure to residues in food and drinking water alone. The petition requested that 40 CFR part 180.662 be amended by establishing tolerances for residues of the herbicide trinexapac-ethyl, (4-(cyclopropyl-a-hydroxy-methylene)-3,5-dioxo-cyclohexanecarboxylic acid ethyl ester), and its primary metabolite CGA-179500 in or on sugarcane, cane at 1.5 parts per million (ppm) and sugarcane, molasses at 5.0 ppm. documents in the last year, by the Centers for Medicare & Medicaid Services Used by homeowners and professional applicators to manage growth of warm and cool-season turfgrass on golf courses, sod farms, residential lawns, and other areas. Our results are consistent with other wheat plant growth regulator research, which has reported similar variation in response among sites and years. Products in this class include flurprimidol, paclobutrazol, ethephon and trinexapac-ethyl. . In 2014 application of Palisade or Palisade plus Tilt significantlyreduced plant height at Chickasha and Perkins. For complete information about, and access to, our official publications This site displays a prototype of a Web 2.0 version of the daily They were not associated with other neuropathological findings or overt neurological signs so their biological significance is unknown. Section 180.662 is added to subpart C to read as follows: (a) General. Register documents. Further information about EPA's risk assessment and determination of safety can be found at http://www.regulations.gov in the document titled Trinexapac-ethyl. This feature is not available for this document. EPA's assessment of exposures and risks associated with trinexapac-ethyl follows. Marietta Echeverria, Registration Division (7505P), Office of Pesticide Programs, Environmental Protection Agency, 1200 Pennsylvania Ave. NW, Washington, DC 20460-0001; main telephone number: (703) 305-7090; email address: RDFRNotices@epa.gov. Upon review of the available information, EPA concludes that these tolerances would be safe. Do not let the chemical enter drains. Therefore, an additional 10x database UF was not retained for lack of inhalation toxicity data and these data are not being required. Acute dietary risks are below the Agency's level of concern: 2.5% of the acute population adjusted dose (aPAD) for females 13 to 49 years old, the population group of concern. The analysis and recommendations made in this blog post are preliminary and based on research findings from 2013. Application of Palidsade or Palisade plus Tilt resulted in numeric reductions in lodging scores at Stillwater in 2013, but the result were too variable to result in statistical significance. Tolerances are established for residues of the plant growth regulator, trinexapac-ethyl, including its metabolites and degradates, in or on the commodities in the table below. Consider lowering your first application rates. What are the uses of Trinexapac-ethyl ? That document contains a summary of the toxicological profile, a reference to toxicological endpoints, a description of EPA's position on the potential for cumulative risk, as well as the rationale for the Agency's determination regarding the children's safety factor. ii. 4. The President of the United States manages the operations of the Executive branch of Government through Executive orders. Palisade is a giberellic acid inhibitor and works primarily by reducing plant height. To summarize our work, we found a trend for one to two inch reductions in plant height when Palisade or Palisade plus Tilt were applied, but this did not consistently translate to increased grain yield. documents in the last year, 983 Separated from food and feedstuffs. 02/28/2023, 43 Lose the iron and calcium. Table 2.2.3, Tolerance Summary for Trinexapac-ethyl summarizes these differences on page 8 of the document, Trinexapac-ethyl: Human Health Risk Assessment for the Section 3 Registration Action on Cereal Grains, Sugarcane, and Grasses Grown for Seed which is located in docket ID number EPA-HQ-OPP-2010-0524. Trade name Tweak Yield and Quality Enhancer Other names: Trinexapac-ethyl 250 g/L EC, CHA 8830 Product Use: Improves the percent of thebaine in Poppies. better and aid in comparing the online edition to the print edition. As to residue levels in food, EPA assumed that residues are present in all commodities at the tolerance level and that 100% of commodities with tolerances are treated with trinexapac-ethyl. 2. Cumulative effects from substances with a common mechanism of toxicity. PUGVIEW FETCH ERROR: 403 Forbidden National Center for Biotechnology Information 8600 Rockville Pike, Bethesda, MD, 20894 USA Contact Policies FOIA HHS Vulnerability Disclosure National Library of Medicine National Institutes of Health iii. documents in the last year, by the Federal Highway Administration Compliance with the tolerance levels specified below is to be determined by measuring only the free and conjugated forms of both trinexapac-ethyl, ethyl 4- (cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylate and trinexapac, 4- (cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylic acid, calculated as the stoichiometric equivalent Wheat lodging is not generally a widespread problem in Oklahoma, but it does occur. Dietary exposure from food and feed uses. %%EOF Federal Register. 1. - Double-bond stereo. Document Drafting Handbook documents in the last year, 24 Open for Comment, Economic Sanctions & Foreign Assets Control, Electric Vehicle Standards and Requirements, Further Advancing Racial Equity and Support for Underserved Communities Through the Federal Government. 272 note). All Reports; All Sectors . The quality of Trinexapac-ethyl 95266-40-3 will be secured by ECHEMI. Recommendations may change as further research is conducted and new information is obtained. All other brand names used on this website are Trademarks of other manufacturers in which proprietary rights may exist. publication in the future. 2. search. the Federal Register. Until the ACFR grants it official status, the XML Substance Name: Trinexapac-ethyl [ISO] RN: 95266-40-3 UNII: Q89W563T9J InChIKey: RVKCCVTVZORVGD-QXMHVHEDSA-N. Register, and does not replace the official print version or the official NO open flames. Acute exposure. EPA has also considered available information concerning the variability of the sensitivities of major identifiable subgroups of consumers, including infants and children. Export Percentage. 321(q), 346a and 371. ii. Avoid formation of dust and aerosols. Key words: Leaf architecture, yield components, plant growth, plant growth regulator, Zea mays L. Please store the product under the recommended conditions in the Certificate of Analysis. It is interesting to note that the Palisade treatment increased grain yield at Perkins even though the plots lodged at comparable levels as the non treated check. documents in the last year, 87 4. Manganese and trinexapac-ethyl are compatible and seem to yield higher turf growth suppression than trinexapac-ethyl and iron. Refer for medical attention. Two comments were received in response to the Notice of Filing. Keep the chemical in suitable and closed containers for disposal. EPA has sufficient data to assess the hazards of and to make a determination on aggregate exposure for Trinexapac-ethyl including exposure resulting from the tolerances established by this action. A Rule by the Environmental Protection Agency on 11/04/2020. Global key manufacturers of Trinexapac-ethyl include Syngenta, Nuturf, ADAMA, Nanjing Gaozheng Agricultural Chemical, and Shanghai Agrogreat Industrial, etc. Nearest Port. Chronic risk. Response to Syngenta's Rebuttal to Plant-back Interval Trinexapac-ethyl End Use Label (Palisade 2EC) and Acceptance Trinexapac-ethyl End Use Label (Palisade EC) and Acceptance Trinexapac-ethyl Technical Label and Letter of Acceptance. search more_vert. Based on the lack of evidence of carcinogenicity in two adequate rodent carcinogenicity studies, trinexapac-ethyl is not expected to pose a cancer risk to humans. The method may be requested from: Chief, Analytical Chemistry Branch, Environmental Science Center, 701 Mapes Rd., Ft. Meade, MD 20755-5350; telephone number: (410) 305-2905; email address: residuemethods@epa.gov. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials. The Office of Management and Budget (OMB) has exempted these types of actions from review under Executive Order 12866, entitled Regulatory Planning and Review (58 FR 51735, October 4, 1993). These tools are designed to help you understand the official document =;Xb`0[,o DUv All objections and requests for a hearing must be in writing, and must be received by the Hearing Clerk on or before January 4, 2021. There is the potential for incidental oral exposure; however, since there is no toxicological endpoint of concern for that route, a quantitative assessment was not conducted. Palisade is a giberellic acid inhibitor and works primarily by reducing plant height. The extract was directly injected into the HPLC system. Document page views are updated periodically throughout the day and are cumulative counts for this document. documents in the last year. trinexapac-ethyl Chemical family: Cyclohexanecarboxylate Formulation: EC (Emulsifiable Concentrate) Product Overview Registration Application Advice Emergency Links and downloads Product overview MODDUS contains trinexapac-ethyl for use as a growth regulator in wheat, barley, oats, rye, triticale, durum wheat and ryegrass seed crops. documents in the last year, 861 documents in the last year, 287 documents in the last year, by the Employment and Training Administration Section 408(b)(2)(D)(v) of FFDCA requires that, when considering whether to establish, modify, or revoke a tolerance, the Agency consider available information concerning the cumulative effects of a particular pesticide's residues and other substances that have a common mechanism of toxicity. EPA has not found trinexapac-ethyl to share a common mechanism of toxicity with any other substances, and trinexapac-ethyl does not appear to produce a toxic metabolite produced by other substances. corresponding official PDF file on govinfo.gov. Information not marked confidential pursuant to 40 CFR part 2 may be disclosed publicly by EPA without prior notice. Therefore, apply trinexapac-ethyl in 20 to 30 gallons of water per acre. documents in the last year, 1408 About the Federal Register C. How can I file an objection or hearing request? Pesticide manufacturing (NAICS code 32532). That notice referenced a summary of the petitions prepared by Syngenta Crop Protection, Inc., the registrant, which is available in the docket, http://www.regulations.gov. 3501 et seq. Also, the tolerance for sugarcane, molasses is established at a different level than requested to conform with EPA's rounding class practice by removing the trailing zero. 02/28/2023, 239 Helps turf withstand the seasonal stresses and is an odorless micro emulsion concentrate. 2023 United States Golf Association. Other names: Trinexapac-ethyl, trimethylsilyl ether Permanent link for this species. documents in the last year, 121 endstream endobj 1017 0 obj <>/Metadata 25 0 R/Pages 1014 0 R/StructTreeRoot 31 0 R/Type/Catalog>> endobj 1018 0 obj <>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/StructParents 0/Tabs/S/Type/Page>> endobj 1019 0 obj <>stream Registration Review. documents in the last year, 83 Petition 0F7719 requested that 40 CFR part 180 be amended by establishing tolerances for residues of the plant growth regulator, trinexapac-ethyl and its primary metabolite CGA-179500, in or on grass, forage, grown for seed at 1.60 parts per million (ppm); grass, hay, grown for seed at 3.5 ppm; grass, seed screenings, grown for seed at 45.0 ppm; grass, straw, grown for seed at 12 ppm; cattle (fat, meat, meat byproducts) at 0.05 ppm; goat (fat, meat, meat byproducts) at 0.05 ppm; horse (fat, meat, meat byproducts) at 0.05 ppm and sheep (fat, meat, meat byproducts) at 0.05 ppm. Use this link for bookmarking this species for future reference. EPA will submit a report containing this rule and other required information to the U.S. Senate, the U.S. House of Representatives, and the Comptroller General of the United States prior to publication of this final rule in the Federal Register. We are conducting the same trial in 2014 along with a separate trial evaluating Palisade in drought stress environments that is partially funded by Syngenta. The Public Inspection page Adequate enforcement methodology (Method GRM020.01A, which utilizes high performance liquid chromatography with triple-quadrupole mass spectrometry (LC-MS/MS)) is available to enforce the tolerance expression. The United States is not able to harmonize its sugarcane tolerance with the Codex MRL; based on the reduction of the preharvest interval (PHI) from 28 to 14 days on sugarcane, the field trial data indicate that use in accordance with the label results in residues may exceed tolerances if they were harmonized with Codex. Many of the proposed tolerances are different from the tolerances being set by EPA. Room temperature in continental US; may vary elsewhere. As such, the Agency has determined that this action will not have a substantial direct effect on States or tribal governments, on the relationship between the national government and the States or tribal governments, or on the distribution of power and responsibilities among the various levels of government or between the Federal Government and Indian tribes. documents in the last year, by the Federal Communications Commission This document has been published in the Federal Register. documents in the last year, 24 02/28/2023, 828 Section 408(b)(2)(A)(i) of FFDCA allows EPA to establish a tolerance (the legal limit for a pesticide chemical residue in or on a food) only if EPA determines that the tolerance is safe. Section 408(b)(2)(A)(ii) of FFDCA defines safe to mean that there is a reasonable certainty that no harm will result from aggregate exposure to the pesticide chemical residue, including all anticipated dietary exposures and all other exposures for which there is reliable information. This includes exposure through drinking water and in residential settings, but does not include occupational exposure. Thus, the Agency has determined that Executive Order 13132, entitled Federalism (64 FR 43255, August 10, 1999) and Executive Order 13175, entitled Consultation and Coordination with Indian Tribal Governments (65 FR 67249, November 9, 2000) do not apply to this action. Enter your email address to follow this blog and receive notifications of new posts by email. documents in the last year. The Public Inspection page The USGA promotes and conserves the true spirit of the game of golf as embodied in its ancient and honorable traditions. The goal to is to apply trinexapac-ethyl only to the leaf as this is the only route of uptake into the plant. documents in the last year, by the Fish and Wildlife Service Most requests are made by state . A summary of the toxicological endpoints for trinexapac-ethyl used for human risk assessment is shown in Table 1 of this unit. Use dry chemical, carbon dioxide or alcohol-resistant foam. documents in the last year, 20 Aggregate Risk Assessment and Determination of Safety, D. Revisions to Petitioned-For Tolerances, VI. with the Chemical Abstracts Service number 95266-40-3. More information and documentation can be found in our establishing the XML-based Federal Register as an ACFR-sanctioned The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Under FFDCA section 408(g), 21 U.S.C. Clethodim. The Public Inspection page may also There are no residual uncertainties in the exposure database. Collect and arrange disposal. the Federal Register. trinexapac-ethyl is approved for use . Because EPA's level of concern for trinexapac-ethyl is a MOE of 100 or below, these MOEs are not of concern. . This action modifies existing tolerances under FFDCA section 408(d) in response to a petition submitted to the Agency. However, the existing legal framework provided by section 408 of FFDCA contemplates that tolerances greater than zero may be set when persons seeking such tolerances or exemptions have demonstrated that the pesticide meets the safety standard imposed by that statute. More information and documentation can be found in our This early-season fungicide application will not, however, substitute for a fungicide application at flag leaf. The trinexapac-ethyl changes the size of the corn p lants, enabling new spatial arrangements. documents in the last year, 662 MODDUS contains trinexapac-ethyl for use as a growth regulator in wheat, barley, oats, rye, triticale, durum wheat and ryegrass seed crops. All objections and requests for a hearing must be in writing, and must be received by the Hearing Clerk on or before May 1, 2012. Ensure adequate ventilation. documents in the last year, 822 Recommendations may change as further research is conducted and new information is obtained. Therefore, EPA is increasing tolerances for residues of trinexapac-ethyl, ethyl 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylate, including Start Printed Page 70064its metabolites and degradates, in or on sugarcane, cane at 1.5 ppm, and sugarcane, molasses at 5 ppm. You may be potentially affected by this action if you are an agricultural producer, food manufacturer, or pesticide manufacturer. The numbers in the figure do not account for harvest losses, which can exceed losses associated with lower photosynthetic capacity shown in the figure. 1503 & 1507. Bethany Benbow, Registration Division (7505P), Office of Pesticide Programs, Environmental Protection Agency, 1200 Pennsylvania Ave. I believe that close interaction with producers is vital to understand their production strategies and to establish realistic research goals. Wheat plant heightas affected by plant growth regulators in 2013, Wheat plant height as affected by plant growth regulator in 2014. In estimating acute dietary exposure, EPA used food consumption information from the U.S. Department of Agriculture (USDA) 1994-1996 and 1998 Nationwide Continuing Surveys of Food Intake by Individuals (CSFII). for better understanding how a document is structured but Trinexapac-ethyl. 601 et seq. Monks, T.G. 21 U.S.C. Incidental oral (short and intermediate-term), No appropriate endpoint for the incidental oral scenario for children, Dermal & Inhalation (short- and intermediate-term-adults only), Dermal (or oral) study NOAEL = 60 mg/kg/day (dermal absorption rate = 77.5%. Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1, H410 Very toxic to aquatic life with long lasting effects. Because this action has been exempted from review under Executive Order 12866, this action is not subject to Executive Order 13211, entitled Actions Concerning Regulations That Significantly Affect Energy Supply, Distribution, or Use (66 FR 28355, May 22, 2001) or Executive Order 13045, entitled Protection of Children from Environmental Health Risks and Safety Risks (62 FR 19885, April 23, 1997), nor is it considered a regulatory action under Executive Order 13771, entitled Reducing Regulations and Controlling Regulatory Costs (82 FR 9339, February 3, 2017). do not apply. 5. The Docket Facility telephone number is (703) 305-5805. Trade Capacity. headings within the legal text of Federal Register documents. Consistent with section 408(b)(2)(D) of FFDCA, and the factors specified in section 408(b)(2)(D) of FFDCA, EPA has reviewed the available scientific data and other relevant information in support of this action. Palisade is a giberellic acid inhibitor and works primarily by reducing plant height. Related Chemical Abstract Service # 95266-40-3: First . Liquid formulations containing organic solvents may be flammable. 1. ACTIVE INGREDIENT / BIOLOGICS / COMBINATION, https://iaspub.epa.gov/apex/pesticides/f?p=PPLS:8:::::P8_PUID,P8_RINUM:495794,9198-245, https://www3.epa.gov/pesticides/chem_search/ppls/009198-00245-20200519.pdf, https://www3.epa.gov/pesticides/chem_search/ppls/009198-00245-20170920.pdf, https://www3.epa.gov/pesticides/chem_search/ppls/009198-00245-20140827.pdf, https://www3.epa.gov/pesticides/chem_search/ppls/009198-00245-20090508.pdf, https://www3.epa.gov/pesticides/chem_search/ppls/009198-00245-20090316.pdf. Submit the non-CBI copy of your objection or hearing request, identified by docket ID number EPA-HQ-OPP-2020-0046, by one of the following methods: Additional instructions on commenting or visiting the docket, along with more information about dockets generally, is available at http://www.epa.gov/dockets. The authority citation for part 180 continues to read as follows: Authority: Containing the same active ingreedient as PRIMO MAXX; PrimeraONE Trinexapac-Ethyl will make your course greener and reduce the number of mowings, saving labor, fuel, and time. While application of Palisade resulted in numeric reductions in plant height at Chickasha and Stillwater, differences among treatments were not statistically significant. Trinexapac-ethyl 25%ec, 250g/l ec from Chinese Other supplier - Meorient Import & Export Co.LTD on tradechina.com . The following five field observations are strategies that may increase the effectiveness of trinexapac-ethyl when applying it for bermudagrass growth suppression: Use a low carrier volume. 346a(d)(3), announcing the filing of a pesticide petition (PP 9F8761) by Syngenta Crop Protection, LLC, P.O. documents in the last year, 474 Chemical Name: Cyclohexanecarboxylic acid, 4-(cyclopropylhydroxymethylene)-3,5-dioxo-, ethyl ester: Announcements. 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